Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22246041 | 0.89 | KMT2A (0.45) | KMT2APTGS1PTGS2ALDH1A1ABCB11 | |
| SCHEMBL22246038 | 0.87 | PTGS2 (0.50) | KMT2APTGS1PTGS2HSD17B1HSD17B2 | |
| SCHEMBL22246020 | 0.87 | PTGS1 (0.57) | KMT2APTGS1PTGS2 | |
| SCHEMBL26200536 | 0.87 | PTGS1 (0.55) | KMT2APTGS1PTGS2ALDH1A1ABCB11 | |
| SCHEMBL22246144 | 0.87 | PRF1 (0.45) | KMT2APTGS1PTGS2HSD17B10CYP2A6 | |
| SCHEMBL22246013 | 0.85 | KMT2A (0.41) | KMT2APTGS1PTGS2HSD17B1HSD17B2 | |
| SCHEMBL26200500 | 0.85 | KMT2A (0.40) | KMT2APTGS1PTGS2ALDH1A1ABCB11 | |
| SCHEMBL22246012 | 0.84 | KMT2A (0.39) | KMT2APTGS1PTGS2ALDH1A1POLB | |
| SCHEMBL22246039 | 0.83 | PTGS1 (0.58) | KMT2APTGS1PTGS2ALDH1A1CYP1A2 | |
| SCHEMBL22246138 | 0.83 | CYP2A6 (0.61) | KMT2ACYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11744826-B2 | Compounds and methods of treating retinal degeneration | CASE WESTERN RESERVE UNIVERSITY (US) | 2023-09-05 | — | — | US | disclosed |
| US-20220087992-A1 | COMPOUNDS AND METHODS OF TREATING RETINAL DEGENERATION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-03-24 | — | — | US | disclosed |
| US-11191752-B2 | Compounds and methods of treating retinal degeneration | CASE WESTERN RESERVE UNIVERSITY (US) | 2021-12-07 | — | — | US | disclosed |
| US-20200230119-A1 | COMPOUNDS AND METHODS OF TREATING RETINAL DEGENERATION | CASE WESTERN RESERVE UNIVERSITY | 2020-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220087992-A1 | COMPOUNDS AND METHODS OF TREATING RETINAL DEGENERATION | ALDH1A2, PDE6D, PDE6C | KMT2A 4688/4885PTGS1 348/4885PTGS2 475/4885 |
| US-20200230119-A1 | COMPOUNDS AND METHODS OF TREATING RETINAL DEGENERATION | PDE6A, PDE6H, PDE6D | KMT2A 4586/4885PTGS1 394/4885PTGS2 766/4885 |
| US-11744826-B2 | Compounds and methods of treating retinal degeneration | ALDH1A2, PDE6D, PDE6C | KMT2A 4688/4885PTGS1 348/4885PTGS2 475/4885 |
| US-11191752-B2 | Compounds and methods of treating retinal degeneration | PDE6A, PDE6H, PDE6D | KMT2A 4586/4885PTGS1 394/4885PTGS2 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.