SCHEMBL22248697

SCHEMBL22248697

Nc1ccn(-c2ccc(CCN3CCNCC3)cc2)c(=O)n1

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 3/20 0.46
KCNJ1 P48048 1/20 0.46
SLC6A4 P31645 2/20 0.44
ROCK2 O75116 4/20 0.43
SLC6A2 P23975 1/20 0.42
SLC6A3 Q01959 1/20 0.42
SIGMAR1 Q99720 3/20 0.42
NOS1 P29475 5/20 0.40
NOS3 P29474 4/20 0.40
MCHR1 Q99705 2/20 0.38
USP28 Q96RU2 1/20 0.36
USP25 Q9UHP3 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA9 Q16790 1/20 0.36
CHRM2 P08172 1/20 0.36
CHRM4 P08173 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22254227 0.95 SIGMAR1 (0.46) KCNH2KCNJ1SLC6A4ROCK2SLC6A2
SCHEMBL22248949 0.84 SPHK1 (0.47) ROCK2NOS1NOS3MCHR1CHRM2
SCHEMBL22254572 0.82 ROCK2 (0.43) ROCK2NOS1NOS3
SCHEMBL22248676 0.82 ROCK2 (0.43) ROCK2SIGMAR1NOS1NOS3MCHR1
SCHEMBL22254225 0.81 ROCK2 (0.44) ROCK2NOS1NOS3MCHR1CHRM2
SCHEMBL22254161 0.81 ROCK2 (0.43) ROCK2NOS1NOS3MCHR1
SCHEMBL22248932 0.81 ROCK2 (0.40) KCNH2ROCK2SIGMAR1NOS1NOS3
SCHEMBL22254209 0.80 ROCK2 (0.45) ROCK2NOS1NOS3MCHR1CHRM2
SCHEMBL22254224 0.80 ROCK2 (0.45) ROCK2NOS1NOS3MCHR1CHRM2
SCHEMBL25532068 0.80 ROCK2 (0.45) ROCK2NOS1NOS3MCHR1CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020150372-A1 ANTIMICROBIAL COMPOUNDS AND METHODS CURZA GLOBAL, LLC (US) 2020-07-23 WO disclosed