SCHEMBL22249174

SCHEMBL22249174

Nc1ccn(-c2cccc(CCN3C[C@H]4C[C@@]4(N)C3)c2)c(=O)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 5/20 0.43
KCNH2 Q12809 4/20 0.32
SIGMAR1 Q99720 3/20 0.32
OPRM1 P35372 2/20 0.32
HTR1A P08908 3/20 0.32
NOS3 P29474 1/20 0.32
NOS1 P29475 1/20 0.32
L3MBTL3 Q96JM7 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
MCHR1 Q99705 1/20 0.31
DRD2 P14416 2/20 0.31
HTR1D P28221 2/20 0.31
HTR1B P28222 2/20 0.31
HTR2A P28223 2/20 0.31
HTR7 P34969 2/20 0.31
DRD3 P35462 2/20 0.31
HTR2B P41595 2/20 0.31
BACE1 P56817 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22248433 0.87 ROCK2 (0.42) ROCK2KCNH2SIGMAR1OPRM1HTR1A
SCHEMBL22248946 0.81 ROCK2 (0.46) ROCK2KCNH2SIGMAR1OPRM1HTR1A
SCHEMBL22248421 0.80 ROCK2 (0.34) ROCK2SIGMAR1OPRM1HTR1AMCHR1
SCHEMBL22254573 0.79 ROCK2 (0.49) ROCK2KCNH2HTR1ANOS3NOS1
SCHEMBL22249185 0.79 ROCK2 (0.45) ROCK2KCNH2OPRM1HTR1ANOS3
SCHEMBL22248658 0.78 ROCK2 (0.45) ROCK2KCNH2SIGMAR1OPRM1NOS3
SCHEMBL22248931 0.78 ROCK2 (0.41) ROCK2SIGMAR1NOS3NOS1L3MBTL3
SCHEMBL22254568 0.77 ROCK2 (0.47) ROCK2KCNH2SIGMAR1NOS3NOS1
Hydrochloric Acid SCHEMBL30276407 0.77 ROCK2 (0.32) ROCK2SIGMAR1OPRM1
SCHEMBL25532044 0.76 ROCK2 (0.52) ROCK2KCNH2SIGMAR1L3MBTL3L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020150372-A1 ANTIMICROBIAL COMPOUNDS AND METHODS CURZA GLOBAL, LLC (US) 2020-07-23 WO disclosed