Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.46 |
| ▸ | JAK2 | O60674 | 8/20 | 0.34 |
| ▸ | JAK3 | P52333 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224684 | 0.88 | JAK1 (0.39) | JAK1JAK2JAK3ALDH1A1TYK2 | |
| SCHEMBL2279205 | 0.87 | JAK1 (0.43) | JAK1JAK2JAK3ALDH1A1TYK2 | |
| SCHEMBL2273996 | 0.83 | JAK1 (0.41) | JAK1JAK2JAK3TYK2ALOX15 | |
| SCHEMBL2280338 | 0.76 | JAK1 (0.68) | JAK1JAK2JAK3ALDH1A1TYK2 | |
| SCHEMBL2282738 | 0.75 | JAK1 (0.37) | JAK1JAK2JAK3TYK2CYP3A4 | |
| SCHEMBL2280645 | 0.74 | JAK1 (0.53) | JAK1JAK2JAK3ALDH1A1TYK2 | |
| SCHEMBL2365117 | 0.73 | JAK2 (0.42) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2280484 | 0.72 | JAK1 (0.39) | JAK1JAK2JAK3TYK2ALOX15 | |
| SCHEMBL2277963 | 0.72 | JAK1 (0.37) | JAK1ALDH1A1 | |
| SCHEMBL2277351 | 0.72 | JAK1 (0.53) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |