Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 13/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 6/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2282738 | 0.89 | JAK1 (0.37) | JAK1JAK2JAK3CYP3A4TYK2 | |
| SCHEMBL2224979 | 0.87 | JAK1 (0.46) | JAK1ALDH1A1JAK2CYP1A2ALOX15 | |
| SCHEMBL2280484 | 0.85 | JAK1 (0.39) | JAK1JAK2ALOX15JAK3TSHR | |
| SCHEMBL2282844 | 0.79 | JAK1 (0.43) | JAK1JAK2JAK3CYP3A4TYK2 | |
| SCHEMBL12385565 | 0.78 | JAK1 (0.62) | JAK1JAK2JAK3CYP3A4TYK2 | |
| SCHEMBL2282949 | 0.77 | JAK1 (0.56) | JAK1JAK2JAK3CYP3A4TYK2 | |
| SCHEMBL2223799 | 0.77 | JAK1 (0.56) | JAK1JAK2JAK3CYP3A4TYK2 | |
| SCHEMBL2224684 | 0.75 | JAK1 (0.39) | JAK1ALDH1A1JAK2JAK3TYK2 | |
| SCHEMBL2278579 | 0.75 | JAK1 (0.47) | JAK1JAK2JAK3CYP3A4TYK2 | |
| SCHEMBL2274431 | 0.74 | JAK1 (0.46) | JAK1JAK2JAK3CYP3A4TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |