Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.39 |
| ▸ | JAK2 | O60674 | 8/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2273996 | 0.89 | JAK1 (0.41) | JAK1JAK2TYK2JAK3TSHR | |
| SCHEMBL2279205 | 0.85 | JAK1 (0.43) | JAK1JAK2TYK2JAK3TSHR | |
| SCHEMBL2284925 | 0.84 | JAK1 (0.44) | JAK1JAK2TYK2JAK3STS | |
| SCHEMBL2282738 | 0.84 | JAK1 (0.37) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2281009 | 0.81 | JAK1 (0.43) | JAK1JAK2TYK2JAK3STS | |
| SCHEMBL2276588 | 0.80 | JAK1 (0.45) | JAK1JAK2TYK2JAK3STS | |
| SCHEMBL2284404 | 0.80 | JAK1 (0.48) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2278688 | 0.77 | JAK1 (0.44) | JAK1JAK2TYK2JAK3CYP11B2 | |
| SCHEMBL2276488 | 0.75 | JAK1 (0.46) | JAK1JAK2TYK2JAK3STS | |
| SCHEMBL2281892 | 0.75 | JAK1 (0.47) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |