Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.39 |
| ▸ | F13A1 | P00488 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | TGM1 | P22735 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2274085 | 0.89 | JAK1 (0.44) | LMNAKMT2ASMN1; SMN2TSHRJAK2 | |
| SCHEMBL2277327 | 0.87 | SMN1; SMN2 (0.40) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2279697 | 0.84 | GRIN2B (0.40) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL2271018 | 0.84 | L3MBTL1 (0.38) | MEN1KMT2AJAK2TYK2JAK3 | |
| SCHEMBL20266928 | 0.83 | JAK2 (0.52) | JAK2TYK2JAK3JAK1 | |
| SCHEMBL21091382 | 0.83 | JAK2 (0.52) | JAK2TYK2JAK3JAK1 | |
| SCHEMBL2272526 | 0.80 | HTR6 (0.46) | JAK2TYK2JAK3KDM4EJAK1 | |
| SCHEMBL2224307 | 0.80 | HTR6 (0.48) | JAK2TYK2JAK3KDM4EJAK1 | |
| SCHEMBL2278047 | 0.79 | JAK2 (0.44) | SMN1; SMN2JAK2TYK2JAK3JAK1 | |
| SCHEMBL2278249 | 0.79 | JAK1 (0.43) | KMT2ASMN1; SMN2JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |