Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23666643 | 0.89 | ALDH1A1 (0.47) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL17115796 | 0.83 | — | — | |
| SCHEMBL22242106 | 0.82 | SMN1; SMN2 (0.49) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL4419213 | 0.82 | ALDH1A1 (0.53) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL15885943 | 0.79 | ALDH1A1 (0.46) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL22253416 | 0.79 | ALDH1A1 (0.46) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL21061054 | 0.78 | ALDH1A1 (0.45) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL24347367 | 0.78 | SMN1; SMN2 (0.45) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL21137768 | 0.78 | KDM4E (0.45) | KDM4EALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL23666647 | 0.76 | FYN (0.38) | ALDH1A1LMNASMN1; SMN2FYNHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112812061-B | N-aryl-1, 2,3, 4-tetrahydroisoquinoline-7-amine compound and application thereof | 苏州恩华生物医药科技有限公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-112812061-A | N-aryl-1, 2,3, 4-tetrahydroisoquinoline-7-amine compound and application thereof | 江苏恩华药业股份有限公司 | 2021-05-18 | — | — | CN | disclosed |
| US-20200231570-A1 | HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS | SAGARD HOLDINGS MANAGER LP, AS ADMINISTRATIVE AGENT (CA) | 2020-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200231570-A1 | HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS | ADORA2A, ADORA3, ADORA1 | KDM4E 4200/4885ALDH1A1 2100/4885LMNA 4458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.