Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 4/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.52 |
| ▸ | JAK2 | O60674 | 6/20 | 0.51 |
| ▸ | JAK3 | P52333 | 6/20 | 0.51 |
| ▸ | JAK1 | P23458 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | DPP4 | P27487 | 2/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30549291 | 1.00 | PANK3 (0.53) | PANK3CHRM4JAK2JAK3JAK1 | |
| SCHEMBL13622620 | 0.89 | KCNH2 (0.55) | PANK3CHRM4JAK2JAK3JAK1 | |
| SCHEMBL2225620 | 0.86 | USP30 (0.49) | PANK3CHRM4JAK2JAK3JAK1 | |
| SCHEMBL30549233 | 0.84 | CHRM4 (0.52) | PANK3CHRM4DPP4GPR119USP30 | |
| SCHEMBL26128171 | 0.84 | CHRM4 (0.52) | PANK3CHRM4DPP4GPR119USP30 | |
| SCHEMBL30549260 | 0.83 | PARP1 (0.45) | CHRM4USP30 | |
| Trifluoroacetic Acid SCHEMBL1023392 | 0.82 | DPP4 (0.56) | PANK3CHRM4KCNH2DPP4GPR119 | |
| SCHEMBL1729679 | 0.82 | CHRM4 (0.48) | PANK3CHRM4JAK2JAK3JAK1 | |
| SCHEMBL15652381 | 0.82 | JAK2 (0.48) | JAK2USP30 | |
| SCHEMBL1729285 | 0.81 | CHRM4 (0.57) | PANK3CHRM4JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523664-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088192-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |