Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.47 |
| ▸ | PANK3 | Q9H999 | 3/20 | 0.47 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | JAK1 | P23458 | 4/20 | 0.44 |
| ▸ | JAK3 | P52333 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2225824 | 0.86 | PANK3 (0.53) | USP30CHRM4PANK3DPP4DPP8 | |
| SCHEMBL30549291 | 0.86 | PANK3 (0.53) | USP30CHRM4PANK3DPP4DPP8 | |
| SCHEMBL21135514 | 0.84 | MAP4K4 (0.52) | CHRM4PANK3DPP4DPP8DPP9 | |
| SCHEMBL12683464 | 0.82 | GPR119 (0.46) | CHRM4PANK3JAK2JAK1JAK3 | |
| SCHEMBL29462081 | 0.78 | RET (0.48) | CHRM4PANK3DPP4DPP8DPP9 | |
| SCHEMBL2224211 | 0.78 | MAP4K4 (0.50) | DPP4DPP8DPP9DPP7PRKCQ | |
| SCHEMBL16718874 | 0.76 | GRM4 (0.48) | CHRM4PANK3DPP4DPP8DPP9 | |
| SCHEMBL6913383 | 0.75 | PIK3CA (0.52) | CHRM4PANK3EIF2AK4DPP4JAK2 | |
| SCHEMBL13622620 | 0.75 | KCNH2 (0.55) | USP30CHRM4PANK3DPP4DPP8 | |
| SCHEMBL16128015 | 0.75 | ALDH1A1 (0.52) | USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523664-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088192-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |