Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.42 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 14/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 7/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13718844 | 0.92 | S1PR1 (0.44) | ITGB3ITGA2BITGA2S1PR1S1PR3 | |
| SCHEMBL2224457 | 0.92 | S1PR1 (0.44) | ITGB3ITGA2BITGA2S1PR1S1PR3 | |
| SCHEMBL2178689 | 0.87 | S1PR1 (0.44) | ITGB3ITGA2BITGA2S1PR1S1PR3 | |
| SCHEMBL2365141 | 0.86 | AKR1C3 (0.46) | GAAATMALDH1A1PKMMAPK1 | |
| SCHEMBL2178623 | 0.85 | ITGB3 (0.42) | ITGB3ITGA2BITGA2S1PR1S1PR3 | |
| SCHEMBL2178629 | 0.85 | ITGB3 (0.42) | ITGB3ITGA2BITGA2S1PR1S1PR3 | |
| SCHEMBL13719612 | 0.84 | AKR1C3 (0.44) | ITGB3ITGA2BITGA2S1PR1S1PR3 | |
| SCHEMBL2181367 | 0.84 | AKR1C3 (0.44) | ITGB3ITGA2BITGA2S1PR1S1PR3 | |
| SCHEMBL13718848 | 0.83 | PLK1 (0.41) | ITGB3ITGA2BITGA2S1PR1S1PR3 | |
| SCHEMBL2177053 | 0.83 | MEN1 (0.45) | ALDH1A1ITGB3ITGA2BITGA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |