Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 15/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224457 | 0.93 | S1PR1 (0.44) | S1PR1S1PR3LMNATP53ITGB3 | |
| SCHEMBL13718844 | 0.93 | S1PR1 (0.44) | S1PR1S1PR3LMNATP53ITGB3 | |
| SCHEMBL2181058 | 0.92 | LMNA (0.42) | S1PR1S1PR3LMNATP53ITGB3 | |
| SCHEMBL2180255 | 0.88 | LMNA (0.51) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2181207 | 0.88 | MEN1 (0.44) | LMNATP53ITGB3ITGA2BITGA2 | |
| SCHEMBL2226163 | 0.87 | GAA (0.45) | S1PR1S1PR3ITGB3ITGA2BITGA2 | |
| SCHEMBL2178623 | 0.85 | ITGB3 (0.42) | S1PR1S1PR3ITGB3ITGA2BITGA2 | |
| SCHEMBL2178629 | 0.85 | ITGB3 (0.42) | S1PR1S1PR3ITGB3ITGA2BITGA2 | |
| SCHEMBL2181367 | 0.85 | AKR1C3 (0.44) | S1PR1S1PR3LMNATP53ITGB3 | |
| SCHEMBL13719612 | 0.85 | AKR1C3 (0.44) | S1PR1S1PR3LMNATP53ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | claimed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | claimed |
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |