SCHEMBL2226518

SCHEMBL2226518

CC(C)(CNC(=O)c1cccc(-c2noc(C(F)(F)F)n2)c1)c1coc(-c2ccccc2)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 15/20 1.00
HDAC1 Q13547 6/20 1.00
HDAC8 Q9BY41 5/20 1.00
HDAC7 Q8WUI4 4/20 1.00
HDAC5 Q9UQL6 4/20 1.00
HDAC9 Q9UKV0 3/20 1.00
HDAC6 Q9UBN7 13/20 0.49
HDAC3 O15379 1/20 0.49
HDAC2 Q92769 1/20 0.49
HDAC10 Q969S8 1/20 0.49
HDAC11 Q96DB2 1/20 0.49
HPGDS O60760 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29370567 1.00 HDAC4 (1.00) HDAC4HDAC1HDAC8HDAC7HDAC5
SCHEMBL2225769 0.94 HDAC4 (0.89) HDAC4HDAC1HDAC8HDAC7HDAC5
SCHEMBL29757316 0.94 HDAC4 (0.88) HDAC4HDAC1HDAC8HDAC7HDAC5
SCHEMBL2226555 0.93 HDAC4 (0.87) HDAC4HDAC1HDAC8HDAC7HDAC5
SCHEMBL14605297 0.91 HDAC4 (0.82) HDAC4HDAC1HDAC8HDAC7HDAC5
SCHEMBL14752448 0.88 HDAC4 (0.79) HDAC4HDAC1HDAC8HDAC7HDAC5
SCHEMBL2228678 0.86 HDAC4 (0.76) HDAC4HDAC1HDAC8HDAC7HDAC5
SCHEMBL2362796 0.83 HDAC4 (0.71) HDAC4HDAC1HDAC8HDAC7HDAC5
SCHEMBL25049598 0.83 HDAC8 (0.71) HDAC4HDAC1HDAC8HDAC7HDAC5
SCHEMBL14752493 0.83 HDAC4 (0.71) HDAC4HDAC1HDAC8HDAC7HDAC5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018057933-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING OXIDATIVE STRESS IN CARDIOMYOCYTES THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2018-03-29 WO claimed
EP-2533783-B1 COMPOUNDS AND METHODS for the inhibition of HDAC TEMPERO PHARMACEUTICALS INC (US) 2015-11-04 EP claimed
US-8901156-B2 Compounds and methods TEMPERO PHARMACEUTICALS, INC. (US) 2014-12-02 US claimed
US-20130059883-A1 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. 2013-03-07 US claimed
WO-2013009830-A1 METHODS OF TREATMENT TEMPERO PHARMACEUTICALS, INC. (US) 2013-01-17 WO claimed
WO-2013009810-A1 METHODS OF TREATMENT TEMPERO PHARMACEUTICALS, INC. (US) 2013-01-17 WO claimed
US-12637433-B2 Histone deacetylase inhibitors THE UNIVERSITY OF QUEENSLAND (AU) 2026-05-26 US disclosed
US-20240109847-A1 HISTONE DEACETYLASE INHIBITORS THE UNIVERSITY OF QUEENSLAND (AU) 2024-04-04 US disclosed
EP-4267539-A1 HISTONE DEACETYLASE INHIBITORS The University of Queensland (AU) 2023-11-01 EP disclosed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2023-09-14 US disclosed
WO-2022133551-A1 HISTONE DEACETYLASE INHIBITORS THE UNIVERSITY OF QUEENSLAND (AU) 2022-06-30 WO disclosed
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE Design Therapeutics, Inc. 2021-09-16 US disclosed
WO-2011088181-A9 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. (US) 2013-01-31 WO disclosed
WO-2011088181-A9 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. (US) 2013-01-31 WO disclosed
WO-2013009810-A1 METHODS OF TREATMENT TEMPERO PHARMACEUTICALS, INC. (US) 2013-01-17 WO disclosed
WO-2013009830-A1 METHODS OF TREATMENT TEMPERO PHARMACEUTICALS, INC. (US) 2013-01-17 WO disclosed
EP-2533783-A1 COMPOUNDS AND METHODS Tempero Pharmaceuticals, Inc. (US) 2012-12-19 EP disclosed
WO-2011088181-A1 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. (US) 2011-07-21 WO disclosed
WO-2011088181-A1 COMPOUNDS AND METHODS TEMPERO PHARMACEUTICALS, INC. (US) 2011-07-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230285573-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 HDAC4 2054/4885HDAC1 1578/4885HDAC8 1533/4885
US-12637433-B2 Histone deacetylase inhibitors HDAC1, HDAC11, HDAC3 HDAC4 10/4885HDAC1 1/4885HDAC8 4/4885
US-20210283265-A1 METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE NEDD4, CBL, UBQLN2 HDAC4 2054/4885HDAC1 1578/4885HDAC8 1533/4885
US-20130059883-A1 COMPOUNDS AND METHODS XDH, LPXN, CCNY HDAC4 1441/4885HDAC1 640/4885HDAC8 1583/4885
US-20240109847-A1 HISTONE DEACETYLASE INHIBITORS HDAC1, HDAC3, HDAC11 HDAC4 10/4885HDAC1 1/4885HDAC8 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.