SCHEMBL2226544

SCHEMBL2226544

CC(C)(C)OC(=O)N1CCCC(F)C1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.55
ALDH1A1 P00352 1/20 0.55
MAPT P10636 1/20 0.55
KMT2A Q03164 1/20 0.55
HPGD P15428 1/20 0.53
EPHX1 P07099 1/20 0.47
USP2 O75604 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
PREP P48147 2/20 0.44
USP30 Q70CQ3 1/20 0.44
RECQL P46063 1/20 0.43
NR1H2 P55055 1/20 0.43
HSD17B10 Q99714 1/20 0.43
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
GLS O94925 1/20 0.41
HPGDS O60760 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4934881 1.00 MEN1 (0.55) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL12524261 1.00 MEN1 (0.55) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL25079350 0.95 HPGD (0.55) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL1733236 0.91 HPGD (0.53) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL3792583 0.91 HPGD (0.53) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL1733238 0.91 HPGD (0.53) MEN1ALDH1A1MAPTKMT2AHPGD
Hydrochloric Acid SCHEMBL30496259 0.90 HPGD (0.51) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL20502507 0.84 CA1 (0.44) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL22737529 0.83 HPGD (0.43) MEN1ALDH1A1MAPTKMT2AHPGD
SCHEMBL22737632 0.83 HPGD (0.43) MEN1ALDH1A1MAPTKMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122070277-A Androgen receptor PROTAC 葛兰素史密斯克莱知识产权发展有限公司 2026-05-19 CN disclosed
EP-4419525-B1 HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER ARTIOS PHARMA LTD (GB) 2025-07-23 EP disclosed
US-20250230165-A1 HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER ARTIOS PHARMA LIMITED (GB) 2025-07-17 US disclosed
CN-119585238-A N- (pyrrolidin-3-yl or piperidin-4-yl) acetamide derivatives 武田药品工业株式会社 2025-03-07 CN disclosed
WO-2025031471-A1 NOVEL HETEROCYCLIC COMPOUND FOR REGULATING P53 FUNCTION 德睿智药(苏州)新药研发有限公司 2025-02-13 WO disclosed
CN-119421882-A FGFR2 inhibitor compounds 伊莱利利公司 2025-02-11 CN disclosed
CN-119343333-A Amino heteroaryl kinase inhibitors 安锐生物医药公司 2025-01-21 CN disclosed
WO-2025002177-A1 P53-Y220C SELECTIVE SMALL-MOLECULAR REACTIVATOR COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF 长春金赛药业有限责任公司 2025-01-02 WO disclosed
CN-118974038-A Heterocyclic compounds and methods of use 薛定谔公司 2024-11-15 CN disclosed
CN-113993872-B EGFR inhibitors for the treatment of cancer 豪夫迈·罗氏有限公司 2024-09-24 CN disclosed
WO-2017174621-A1 PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2017-10-12 WO disclosed
WO-2017174620-A1 BENZO[B]FURANS AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2017-10-12 WO disclosed
EP-2922851-B1 AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS GENENTECH INC (US) 2017-07-26 EP disclosed
US-20170183342-A1 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR MERCK SHARP & DOHME LLC 2017-06-29 US disclosed
EP-3181564-A1 AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS Genentech, Inc. (US) 2017-06-21 EP disclosed
WO-2017100668-A1 INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE JANSSEN PHARMACEUTICA NV (BE) 2017-06-15 WO disclosed
EP-2970201-A1 6-[4-(1 H-IMIDAZOL-2-YL)PIPERIDIN-1 -YL]PYRIMIDIN-4-AMINE DERIVATIVES AS MODULATORS OF KINASE ACTIVITY Merck Patent GmbH (DE) 2016-01-20 EP disclosed
WO-2014143612-A1 6-[4-(1 H-IMIDAZOL-2-YL)PIPERIDIN-1 -YL]PYRIMIDIN-4-AMINE DERIVATIVES AS MODULATORS OF KINASE ACTIVITY MERCK PATENT GMBH (DE) 2014-09-18 WO disclosed
WO-2012016217-A1 AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2012-02-02 WO disclosed
WO-2011086053-A1 TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2011-07-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170183342-A1 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR CHRM5, CHRM4, CHRM1 MEN1 3337/4885ALDH1A1 2056/4885MAPT 828/4885
US-20250230165-A1 HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER NQO1, VHL, SDHA MEN1 504/4885ALDH1A1 174/4885MAPT 3497/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.