SCHEMBL22265458

SCHEMBL22265458

CC(C)(C)OC(=O)N1CCC(Cc2cc(F)c(F)c(Cl)c2)CC1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 7/20 0.47
DPP4 P27487 1/20 0.47
SCN9A Q15858 1/20 0.46
STS P08842 3/20 0.45
KAT8 Q9H7Z6 2/20 0.44
KAT6A Q92794 1/20 0.44
KAT5 Q92993 1/20 0.44
KDM4E B2RXH2 2/20 0.44
PKM P14618 1/20 0.44
TLR7 Q9NYK1 1/20 0.43
TP53 P04637 1/20 0.42
MAPT P10636 1/20 0.42
THRB P10828 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18280182 0.92 DPP4 (0.51) GPR119DPP4SCN9AKDM4EPKM
SCHEMBL15536555 0.86 CCR3 (0.53) GPR119DPP4SCN9ASTSKDM4E
SCHEMBL22265974 0.86 GPR119 (0.49) GPR119DPP4SCN9ASTSKDM4E
SCHEMBL16113557 0.83 GPR119 (0.49) GPR119DPP4SCN9AKDM4EPKM
SCHEMBL17061863 0.83 STS (0.61) GPR119STSKDM4EPKMTP53
SCHEMBL22265765 0.83 STS (0.53) GPR119DPP4SCN9ASTSKDM4E
SCHEMBL18280030 0.82 DPP4 (0.52) GPR119DPP4SCN9AKDM4EPKM
SCHEMBL2452509 0.82 CCR3 (0.52) GPR119STSKDM4EPKMTP53
SCHEMBL30679858 0.82 GPR119 (0.49) GPR119DPP4SCN9AKDM4EPKM
SCHEMBL23365175 0.82 CYP2C9 (0.49) PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12268687-B2 Compounds and uses thereof JANSSEN PHARMACEUTICA NV (BE) 2025-04-08 US disclosed
US-20250034125-A1 COMPOUNDS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2025-01-30 US disclosed
US-20250034124-A1 COMPOUNDS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2025-01-30 US disclosed
US-12098146-B2 Compounds and uses thereof JANSSEN PHARMACEUTICA NV (BE) 2024-09-24 US disclosed
US-20230116101-A1 COMPOUNDS AND USES THEREOF YUMANITY THERAPEUTICS, INC. 2023-04-13 US disclosed
CN-113906019-A Compound and use thereof 优曼尼蒂治疗公司 2022-01-07 CN disclosed
EP-3914593-A1 COMPOUNDS AND USES THEREOF Yumanity Therapeutics, Inc. (US) 2021-12-01 EP disclosed
WO-2021097240-A1 COMPOUNDS AND USES THEREOF YUMANITY THERAPEUTICS, INC. (US) 2021-05-20 WO disclosed
US-20210139471-A1 COMPOUNDS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2021-05-13 US disclosed
US-20210139471-A1 COMPOUNDS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2021-05-13 US disclosed
WO-2020154571-A1 COMPOUNDS AND USES THEREOF YUMANITY THERAPEUTICS, INC. (US) 2020-07-30 WO disclosed
WO-2020154571-A1 COMPOUNDS AND USES THEREOF YUMANITY THERAPEUTICS, INC. (US) 2020-07-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250034124-A1 COMPOUNDS AND USES THEREOF NLN, BDNF, NQO1 GPR119 3998/4885DPP4 2008/4885SCN9A 3417/4885
US-12268687-B2 Compounds and uses thereof NLN, BDNF, NQO1 GPR119 3998/4885DPP4 2008/4885SCN9A 3417/4885
US-20230116101-A1 COMPOUNDS AND USES THEREOF NLN, BDNF, NQO1 GPR119 3998/4885DPP4 2008/4885SCN9A 3417/4885
US-20250034125-A1 COMPOUNDS AND USES THEREOF NLN, BDNF, NQO1 GPR119 3998/4885DPP4 2008/4885SCN9A 3417/4885
US-20210139471-A1 COMPOUNDS AND USES THEREOF NLN, BDNF, NQO1 GPR119 3998/4885DPP4 2008/4885SCN9A 3417/4885
US-12098146-B2 Compounds and uses thereof NLN, BDNF, NQO1 GPR119 3998/4885DPP4 2008/4885SCN9A 3417/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.