Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CLPP | Q16740 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22265471 | 1.00 | HSD11B1 (0.44) | HSD11B1DGAT1GRM5MEN1KMT2A | |
| SCHEMBL22280492 | 0.89 | SPHK2 (0.41) | HSD11B1DGAT1GRM5MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL22265583 | 0.88 | SPHK2 (0.40) | HSD11B1DGAT1GRM5MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL22265586 | 0.88 | SPHK2 (0.40) | HSD11B1DGAT1GRM5MEN1KMT2A | |
| SCHEMBL29522926 | 0.88 | HDAC6 (0.43) | HSD11B1DGAT1ALDH1A1SMN1; SMN2 | |
| SCHEMBL22265594 | 0.83 | HSD11B1 (0.52) | HSD11B1DGAT1GRM5ALDH1A1SMN1; SMN2 | |
| SCHEMBL22265591 | 0.83 | HSD11B1 (0.52) | HSD11B1DGAT1GRM5ALDH1A1SMN1; SMN2 | |
| SCHEMBL22265688 | 0.83 | SMO (0.38) | HSD11B1DGAT1GRM5ALDH1A1SMN1; SMN2 | |
| SCHEMBL22265686 | 0.83 | SMO (0.38) | HSD11B1DGAT1GRM5ALDH1A1SMN1; SMN2 | |
| SCHEMBL22265691 | 0.83 | SMO (0.38) | HSD11B1DGAT1GRM5ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3914592-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | University of Virginia Patent Foundation (US) | 2021-12-01 | — | — | EP | disclosed |
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |