Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22265691 | 1.00 | SMO (0.38) | SMOHSD11B1ALDH1A1KITKDM4E | |
| SCHEMBL22265688 | 1.00 | SMO (0.38) | SMOHSD11B1ALDH1A1KITKDM4E | |
| SCHEMBL29523791 | 0.95 | SMO (0.38) | SMOHSD11B1ALDH1A1KITKDM4E | |
| SCHEMBL29522926 | 0.87 | HDAC6 (0.43) | SMOHSD11B1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL22265592 | 0.85 | SMN1; SMN2 (0.42) | SMOHSD11B1ALDH1A1KDM4EGAA | |
| SCHEMBL22265599 | 0.85 | SMN1; SMN2 (0.42) | SMOHSD11B1ALDH1A1KDM4EGAA | |
| SCHEMBL22265596 | 0.85 | SMN1; SMN2 (0.42) | SMOHSD11B1ALDH1A1KDM4EGAA | |
| SCHEMBL22265471 | 0.83 | HSD11B1 (0.44) | HSD11B1ALDH1A1SMN1; SMN2DGAT1GRM5 | |
| SCHEMBL22265474 | 0.83 | HSD11B1 (0.44) | HSD11B1ALDH1A1SMN1; SMN2DGAT1GRM5 | |
| SCHEMBL29523162 | 0.82 | SMO (0.42) | SMOHSD11B1MAPTSMN1; SMN2DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3914592-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | University of Virginia Patent Foundation (US) | 2021-12-01 | — | — | EP | disclosed |
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |