Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.67 |
| ▸ | CA3 | P07451 | 1/20 | 0.67 |
| ▸ | CA4 | P22748 | 1/20 | 0.67 |
| ▸ | CA6 | P23280 | 1/20 | 0.67 |
| ▸ | CA5A | P35218 | 1/20 | 0.67 |
| ▸ | CA7 | P43166 | 1/20 | 0.67 |
| ▸ | CA9 | Q16790 | 1/20 | 0.67 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.67 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.67 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687206 | 0.81 | SMN1; SMN2 (0.64) | CA12CA1CA2CA3CA4 | |
| SCHEMBL31520571 | 0.81 | SMN1; SMN2 (0.64) | CA12CA1CA2CA3CA4 | |
| SCHEMBL2442745 | 0.81 | CA1 (1.00) | CA12CA1CA2CA3CA4 | |
| SCHEMBL18580 | 0.81 | NR3C2 (0.64) | CA12CA1CA2CA3CA4 | |
| Hydrochloric Acid SCHEMBL5344901 | 0.79 | SMN1; SMN2 (0.61) | CA12CA1CA2CA3CA4 | |
| SCHEMBL10617367 | 0.79 | CA1 (0.95) | CA12CA1CA2CA3CA4 | |
| SCHEMBL11512091 | 0.79 | CA1 (0.95) | CA12CA1CA2CA3CA4 | |
| SCHEMBL27420174 | 0.79 | CA1 (0.59) | CA12CA1CA2CA3CA4 | |
| Hydrochloric Acid SCHEMBL1807459 | 0.79 | NR3C2 (0.62) | CA12CA1CA2CA3CA4 | |
| SCHEMBL11514359 | 0.79 | NR3C2 (0.62) | CA12CA1CA2CA3CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523559-A1 | COMPOUNDS AND METHODS | GlaxoSmithKline LLC (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088027-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-07-21 | — | — | WO | disclosed |