Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752269 | 0.98 | LTA4H (0.64) | LTA4HHRH3 | |
| SCHEMBL9097701 | 0.93 | LTA4H (0.66) | LTA4HHRH3KCNH2 | |
| SCHEMBL9122265 | 0.88 | LTA4H (0.77) | LTA4H | |
| SCHEMBL211606 | 0.88 | LTA4H (0.77) | LTA4H | |
| SCHEMBL5331925 | 0.88 | HRH3 (0.67) | LTA4HHRH3KCNH2 | |
| SCHEMBL22266165 | 0.86 | LTA4H (0.58) | LTA4HHRH3 | |
| SCHEMBL22266156 | 0.86 | LTA4H (0.65) | LTA4HHRH3 | |
| SCHEMBL491550 | 0.85 | HRH3 (0.79) | HRH3KCNH2HRH4 | |
| SCHEMBL492176 | 0.85 | HRH3 (0.79) | HRH3KCNH2HRH4 | |
| SCHEMBL16314571 | 0.84 | HRH3 (0.58) | LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723717-B2 | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides | ARVINAS OPERATIONS, INC. (US) | 2020-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10723717-B2 | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides | CRBN, ARAF, VHL | LTA4H 3562/4885HRH3 3690/4885KCNH2 4861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.