Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 6/20 | 0.52 |
| ▸ | TIPARP | Q7Z3E1 | 4/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.44 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2225124 | 0.97 | HDAC6 (0.50) | HDAC4TIPARPHDAC6HDAC8HDAC2 | |
| SCHEMBL2227789 | 0.88 | HDAC4 (0.62) | HDAC4HDAC6HDAC8HDAC2LMNA | |
| SCHEMBL2224355 | 0.87 | HDAC6 (0.44) | HDAC4TIPARPHDAC6HDAC8HDAC2 | |
| SCHEMBL6913640 | 0.87 | HDAC4 (0.54) | HDAC4HDAC6HDAC8HDAC2ALDH1A1 | |
| SCHEMBL2224008 | 0.86 | HDAC6 (0.48) | HDAC4TIPARPHDAC6HDAC8HDAC2 | |
| SCHEMBL2225828 | 0.86 | PARP1 (0.45) | TIPARPHDAC6HDAC8PARP1 | |
| SCHEMBL2226039 | 0.86 | CHRM1 (0.44) | HDAC4TIPARPHDAC6HDAC8HDAC2 | |
| SCHEMBL2226710 | 0.86 | HDAC6 (0.48) | HDAC4TIPARPHDAC6HDAC8HDAC2 | |
| SCHEMBL2224823 | 0.86 | GRM5 (0.42) | HDAC4TIPARPHDAC6HDAC8 | |
| SCHEMBL13838822 | 0.86 | HDAC6 (0.47) | HDAC4TIPARPHDAC6HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8981084-B2 | Oxadiazole HDAC inhibitors | TEMPERO PHARMACEUTICALS, INC. (US) | 2015-03-17 | — | — | US | claimed |
| WO-2013009827-A1 | METHODS OF TREATMENT | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-01-17 | — | — | WO | claimed |
| US-20120289495-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals Inc. | 2012-11-15 | — | — | US | claimed |
| US-20200268720-A1 | METHODS OF USE OF A CLASS IIA HDAC INHIBITOR | GLAXOSMITHKLINE LLC | 2020-08-27 | — | — | US | disclosed |
| EP-3393458-A1 | METHODS OF USE OF A CLASS llA HDAC INHIBITOR | GlaxoSmithKline LLC (US) | 2018-10-31 | — | — | EP | disclosed |
| WO-2017112838-A1 | METHODS OF USE OF A CLASS llA HDAC INHIBITOR | GLAXOSMITHKLINE LLC (US) | 2017-06-29 | — | — | WO | disclosed |
| US-8981084-B2 | Oxadiazole HDAC inhibitors | TEMPERO PHARMACEUTICALS, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8981084-B2 | Oxadiazole HDAC inhibitors | TEMPERO PHARMACEUTICALS, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-8981084-B2 | Oxadiazole HDAC inhibitors | TEMPERO PHARMACEUTICALS, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| WO-2013009827-A1 | METHODS OF TREATMENT | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-01-17 | — | — | WO | disclosed |
| EP-2523664-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| US-20120289495-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals Inc. | 2012-11-15 | — | — | US | disclosed |
| US-20120289495-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals Inc. | 2012-11-15 | — | — | US | disclosed |
| US-20120289495-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals Inc. | 2012-11-15 | — | — | US | disclosed |
| WO-2011088192-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200268720-A1 | METHODS OF USE OF A CLASS IIA HDAC INHIBITOR | HDAC7, HDAC8, HDAC5 | HDAC4 7/4885TIPARP 649/4885HDAC6 9/4885 |
| US-20120289495-A1 | COMPOUNDS AND METHODS | XDH, CCNY, TOP2B | HDAC4 2773/4885TIPARP 4018/4885HDAC6 1763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.