Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224546 | 0.92 | KDM4C (0.38) | GRM5GPR119NR1H2NR1H3LTB4R | |
| SCHEMBL6895214 | 0.84 | GRM5 (0.40) | GRM5GPR119NR1H2NR1H3KLK7 | |
| SCHEMBL2227389 | 0.83 | GRM5 (0.41) | GRM5NR1H2NR1H3 | |
| SCHEMBL2227962 | 0.83 | GRM5 (0.38) | GRM5GPR119NR1H2NR1H3USP30 | |
| SCHEMBL2226108 | 0.83 | GRM5 (0.40) | GRM5GPR119NR1H2NR1H3ALDH1A1 | |
| SCHEMBL6897230 | 0.82 | FFAR4 (0.34) | GRM5GPR119NR1H2NR1H3 | |
| SCHEMBL2228079 | 0.82 | ALDH1A1 (0.41) | GRM5USP30MEN1ALDH1A1KMT2A | |
| SCHEMBL2223788 | 0.79 | NR1H2 (0.38) | GRM5GPR119NR1H2NR1H3 | |
| SCHEMBL2225594 | 0.78 | USP30 (0.43) | GRM5NR1H2NR1H3USP30RXRA | |
| SCHEMBL2224934 | 0.76 | GRM5 (0.38) | GRM5GPR119NR1H2NR1H3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150368257-A1 | Tricyclic Derivatives and Their Pharmaceutical Use and Compositions | CEPHALON, INC. | 2015-12-24 | — | — | US | disclosed |
| US-9115147-B2 | Tricyclic derivatives and their pharmaceutical use and compositions | CEPHALON, INC. (US) | 2015-08-25 | — | — | US | disclosed |
| EP-2792678-A1 | Tricyclic derivatives and their pharmaceutical use and compositions | CEPHALON, INC. (US) | 2014-10-22 | — | — | EP | disclosed |
| EP-2516446-B1 | SUBSTITUTED HEXAHYDROCHROMENO[3,4-B]PYRROLES WITH AFFINITY FOR THE SEROTONIN RECEPTOR (5-HT) FAMILY | CEPHALON INC (US) | 2014-08-13 | — | — | EP | disclosed |
| US-20120277186-A1 | Tricyclic Derivatives and Their Pharmaceutical Use and Compositions | CEPHALON, INC. (US) | 2012-11-01 | — | — | US | disclosed |
| EP-2516446-A2 | SUBSTITUTED HEXAHYDROCHROMENO[3,4-B]PYRROLES WITH AFFINITY FOR THE SEROTONIN RECEPTOR (5-HT) FAMILY | Cephalon, Inc. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011087713-A2 | TRICYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | CEPHALON, INC. (US) | 2011-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368257-A1 | Tricyclic Derivatives and Their Pharmaceutical Use and Compositions | CYP11B2, CYP11B1, CYP4A11 | GRM5 2804/4885GPR119 1740/4885NR1H2 456/4885 |
| US-20120277186-A1 | Tricyclic Derivatives and Their Pharmaceutical Use and Compositions | CYP11B2, CYP11B1, CYP4A11 | GRM5 2804/4885GPR119 1740/4885NR1H2 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.