SCHEMBL22268484

SCHEMBL22268484

CC(C)(C)c1ccc2c(c1)c1cc(C(C)(C)C)ccc1n2-c1cc(C#N)ccc1-c1nc(-c2ccccc2)cc(-c2ccccc2)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 6/20 0.40
ABCB1 P08183 4/20 0.40
CTSK P43235 2/20 0.36
CTSS P25774 1/20 0.36
CSNK1D P48730 4/20 0.36
CSNK1G2 P78368 4/20 0.36
CSNK1A1 P48729 2/20 0.36
JAK2 O60674 1/20 0.36
PRKD3 O94806 1/20 0.36
ABL1 P00519 1/20 0.36
EGFR P00533 1/20 0.36
ERBB2 P04626 1/20 0.36
LCK P06239 1/20 0.36
CDK1 P06493 1/20 0.36
CSF1R P07333 1/20 0.36
LYN P07948 1/20 0.36
RET P07949 1/20 0.36
KIT P10721 1/20 0.36
FGFR1 P11362 1/20 0.36
FER P16591 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22268452 0.97 ABCG2 (0.40) ABCG2ABCB1CTSKCTSSCSNK1D
SCHEMBL20114525 0.93 ABCG2 (0.39) ABCG2ABCB1CSNK1DCSNK1G2CSNK1A1
SCHEMBL20867351 0.91 ABCG2 (0.38) ABCG2ABCB1CTSKCTSSCSNK1D
SCHEMBL22268417 0.91 ABCG2 (0.39) ABCG2ABCB1CTSKCTSSCSNK1D
SCHEMBL20867514 0.90 ABCG2 (0.40) ABCG2ABCB1CTSKCTSSCSNK1D
SCHEMBL22268460 0.90 ABCG2 (0.41) ABCG2ABCB1CTSKCSNK1DCSNK1G2
SCHEMBL20114528 0.90 CYP1A2 (0.38) ABCG2ABCB1CSNK1DCSNK1G2CLK4
SCHEMBL22268414 0.88 ABCG2 (0.40) ABCG2ABCB1CTSKCTSSCSNK1D
SCHEMBL27016017 0.88 KIF11 (0.40) ABCG2ABCB1CSNK1DCSNK1G2CLK4
SCHEMBL28367118 0.88 KIF11 (0.41) CSNK1DCSNK1G2CSNK1A1KIF11GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3392247-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-07-29 EP disclosed