Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22387461 | 1.00 | POLB (0.37) | POLBALDH1A1LMNAHPGDMAPT | |
| SCHEMBL22270906 | 1.00 | POLB (0.37) | POLBALDH1A1LMNAHPGDMAPT | |
| SCHEMBL1188768 | 0.79 | POLB (0.41) | POLBALDH1A1LMNAKMT2ACYP3A4 | |
| SCHEMBL22387388 | 0.78 | ALDH1A1 (0.32) | POLBALDH1A1LMNAHPGDMAPT | |
| SCHEMBL15106112 | 0.77 | CYP3A4 (0.45) | POLBALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL22387462 | 0.74 | L3MBTL1 (0.36) | ALDH1A1LMNANPSR1CYP3A4CYP2C19 | |
| SCHEMBL15114497 | 0.74 | POLB (0.39) | POLBALDH1A1LMNAKMT2ACYP3A4 | |
| SCHEMBL15105917 | 0.74 | POLB (0.39) | POLBALDH1A1LMNAKMT2ACYP3A4 | |
| SCHEMBL15125259 | 0.74 | POLB (0.39) | POLBALDH1A1LMNAKMT2ACYP3A4 | |
| SCHEMBL22270908 | 0.72 | ALDH1A1 (0.37) | ALDH1A1LMNAHPGDMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3686196-A1 | POLYCYCLIC COMPOUND ACTING AS IDO INHIBITOR AND/OR IDO-HDAC DUAL INHIBITOR | Hangzhou Innogate Pharma Co., Ltd. (CN) | 2020-07-29 | — | — | EP | disclosed |