SCHEMBL2227331

SCHEMBL2227331

CC(C)[C@@H]([C]=O)NC(=O)[C@@H](N)CCCNC(=N)N

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NPY4R P50391 12/20 0.44
NPY1R P25929 7/20 0.44
NPY2R P49146 5/20 0.44
NPY5R Q15761 5/20 0.44
DPP7 Q9UHL4 3/20 0.40
GNAI3 P08754 1/20 0.36
GNAO1 P09471 1/20 0.36
GNAI1 P63096 1/20 0.36
DPP4 P27487 2/20 0.35
DPP8 Q6V1X1 2/20 0.35
DPP9 Q86TI2 2/20 0.35
RRM1 P23921 1/20 0.35
SLC15A1 P46059 1/20 0.34
CTSC P53634 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8507718 1.00 NPY4R (0.44) NPY4RNPY1RNPY2RNPY5RDPP7
SCHEMBL3042600 0.88 NPY4R (0.42) NPY4RNPY1RNPY2RNPY5RDPP7
SCHEMBL4099155 0.87 NPY4R (0.39) NPY4RNPY1RNPY2RNPY5RDPP7
SCHEMBL27824286 0.86 NPY4R (0.45) NPY4RNPY1RNPY2RNPY5RDPP7
SCHEMBL19435658 0.86 NPY4R (0.45) NPY4RNPY1RNPY2RNPY5RDPP7
SCHEMBL22903053 0.83 NPY4R (0.48) NPY4RNPY1RNPY2RNPY5RDPP7
SCHEMBL4086556 0.82 NPY4R (0.55) NPY4RNPY1RNPY2RNPY5R
SCHEMBL1521191 0.82 NPY4R (0.41) NPY4RNPY1RNPY2RNPY5RDPP7
SCHEMBL1521188 0.82 NPY4R (0.41) NPY4RNPY1RNPY2RNPY5RDPP7
SCHEMBL2183420 0.82 NPY4R (0.41) NPY4RNPY1RNPY2RNPY5RDPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101693736-B Novel peptides 寒川贤治 2020-09-11 CN disclosed
US-9938332-B2 Modified ghrelin peptides Kanagawa, Kenji (JP) 2018-04-10 US disclosed
US-9573986-B2 Modified ghrelin peptides KENJI KANGAWA (JP) 2017-02-21 US disclosed
US-8524871-B2 Modified gherlin peptides Kangawa, Kenji (JP) 2013-09-03 US disclosed
US-20130172251-A1 MODIFIED GHRELIN PEPTIDES KANGAWA KENJI (JP) 2013-07-04 US disclosed
US-8227570-B2 Modified gherlin peptides Kanagawa, Kenji (JP) 2012-07-24 US disclosed
US-20110184153-A1 MODIFIED GHERLIN PEPTIDES KANGAWA KENJI 2011-07-28 US disclosed
US-20090170763-A1 Modified gherlin peptides KANGAWA KENJI 2009-07-02 US disclosed
US-6022696-A SCREENING FOR MODULATORS OF INTERACTIONS BETWEEN ANGIOTENSIN LIGANDS AND ANGIOTENSIN RECEPTORS; ADDING ANGIOTENSIN LIGAND TO SAMPLE, ADDING ANGIOTENSIN LIGAND AND MODULATOR TO SECOND SAMPLE, DETERMINING BINDING CHARACTERISTICS WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION (US) 2000-02-08 US disclosed
US-5945457-A Process for preparing biologically compatible polymers and their use in medical devices A.V. TOPCHIEV INSTITUTE OF PETROCHEMICAL SYNTHESIS, RUSSIAN ACADEMY OF SCIENCE (RU) 1999-08-31 US disclosed
EP-0647239-A4 ANGIOTENSIN IV PEPTIDES AND RECEPTOR. UNIV WASHINGTON (US) 1997-07-02 EP disclosed
EP-0647239-A1 ANGIOTENSIN IV PEPTIDES AND RECEPTOR WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION (US) 1995-04-12 EP disclosed
WO-1994000492-A1 ANGIOTENSIN IV PEPTIDES AND RECEPTOR WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION (US) 1994-01-06 WO disclosed
EP-0208785-B1 FIBRINOPHILIC UROKINASE COMPLEX AND PROCESS FOR ITS PREPARATION SHISEIDO COMPANY LIMITED (JP) 1992-12-30 EP disclosed
US-5004609-A Complex with enzyme inhibitor as plasminogen activator; anticoagulants SHISEIDO COMPANY LTD. (JP) 1991-04-02 US disclosed
US-4851345-A ABSORPTION DURING FIBRIN CHROMATOGRAPHY, THEN NON-ABSORPTION IN LYSINE CHROMATOGRAPHY TERUMO KABUSHIKI KAISHA (JP) 1989-07-25 US disclosed
EP-0181596-B1 PROCESS FOR PREPARING A UROKINASE COMPLEX TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION (JP) 1989-03-22 EP disclosed
WO-1987003878-A1 NEW 8-SUBSTITUTED DERIVATIVES OF AN ANHYDROOCTONIC ACID, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THESE AND INTERMEDIATES Astra Läkemedel Aktiebolag (SE) 1987-07-02 WO disclosed
EP-0208785-A1 FIBRINOPHILIC UROKINASE COMPLEX AND PROCESS FOR ITS PREPARATION SHISEIDO COMPANY LIMITED (JP) 1987-01-21 EP disclosed
EP-0181596-A2 Process for preparing a urokinase complex TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION (JP) 1986-05-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110184153-A1 MODIFIED GHERLIN PEPTIDES GHSR, GHRHR, GHITM NPY4R 40/4885NPY1R 92/4885NPY2R 73/4885
US-20090170763-A1 Modified gherlin peptides GHSR, GHRHR, GHITM NPY4R 40/4885NPY1R 92/4885NPY2R 73/4885
US-20130172251-A1 MODIFIED GHRELIN PEPTIDES GHSR, GIPR, GHRHR NPY4R 20/4885NPY1R 31/4885NPY2R 33/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.