Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653129 | 0.83 | KDM4E (0.50) | KDM4ELMNAMAPTGAAHSD17B10 | |
| SCHEMBL6140971 | 0.76 | TP53 (0.59) | KDM4ELMNAPOLBAPEX1CASP6 | |
| SCHEMBL11476060 | 0.75 | KDM4E (0.55) | KDM4ELMNATDP1MAPTGAA | |
| SCHEMBL3156791 | 0.75 | MAPT (0.60) | KDM4ELMNAPOLBTDP1MAPT | |
| SCHEMBL5793163 | 0.73 | ALDH1A1 (0.61) | KDM4ELMNAPOLBTDP1MAPT | |
| SCHEMBL6052447 | 0.73 | ALDH1A1 (0.61) | KDM4ELMNAPOLBTDP1MAPT | |
| SCHEMBL6141020 | 0.72 | NR4A1 (0.51) | KDM4ELMNAPOLBAPEX1CASP6 | |
| SCHEMBL6140202 | 0.72 | GAA (0.44) | KDM4EPOLBAPEX1CASP6CTDSP1 | |
| SCHEMBL11482620 | 0.71 | KDM4E (0.54) | KDM4ELMNAPOLBMAPTGAA | |
| SCHEMBL22273612 | 0.71 | KDM4E (0.42) | KDM4EPOLBTDP1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3915978-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | Hangzhou Yirui Pharmaceutical Technology Co., Ltd (CN) | 2021-12-01 | — | — | EP | disclosed |
| WO-2020151687-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | 杭州壹瑞医药科技有限公司 | 2020-07-30 | — | — | WO | disclosed |