Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29564372 | 0.75 | KDM4E (0.56) | KDM4EHPGDTSHRHSD17B10ALDH1A1 | |
| SCHEMBL22273614 | 0.71 | KDM4E (0.51) | KDM4EHPGDHSD17B10ALDH1A1GAA | |
| SCHEMBL22273578 | 0.71 | KDM4E (0.53) | KDM4EHPGDTSHRHSD17B10ALDH1A1 | |
| SCHEMBL22273618 | 0.71 | MAP3K8 (0.53) | KDM4EHPGDTSHRHSD17B10ALDH1A1 | |
| SCHEMBL29564114 | 0.70 | NR3C1 (0.45) | ALDH1A1GAAPOLB | |
| SCHEMBL22273613 | 0.70 | NR3C1 (0.45) | ALDH1A1GAAPOLB | |
| SCHEMBL28296408 | 0.70 | LTA4H (0.43) | KDM4EHPGDHSD17B10BRD4ALDH1A1 | |
| Ethoxycarbonyl Group SCHEMBL28296409 | 0.69 | ALDH1A1 (0.41) | KDM4EHPGDHSD17B10ALDH1A1GAA | |
| SCHEMBL29563987 | 0.67 | ALDH1A1 (0.66) | ALDH1A1GAAPOLBMAPTTDP1 | |
| SCHEMBL3278560 | 0.65 | GAA (0.57) | HPGDTSHRALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11993576-B2 | N-benzyl-N-arylsulfonamide derivative and preparation and use thereof | HANGZHOU YIRUI PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) | 2024-05-28 | — | — | US | disclosed |
| US-20220089555-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | HANGZHOU YIRUI PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) | 2022-03-24 | — | — | US | disclosed |
| EP-3915978-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | Hangzhou Yirui Pharmaceutical Technology Co., Ltd (CN) | 2021-12-01 | — | — | EP | disclosed |
| EP-3915978-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | Hangzhou Yirui Pharmaceutical Technology Co., Ltd (CN) | 2021-12-01 | — | — | EP | disclosed |
| WO-2020151687-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | 杭州壹瑞医药科技有限公司 | 2020-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11993576-B2 | N-benzyl-N-arylsulfonamide derivative and preparation and use thereof | KCNB1, KCNB2, KCNA3 | KDM4E 247/4885HPGD 3002/4885TSHR 2382/4885 |
| US-20220089555-A1 | N-BENZYL-N-ARYLSULFONAMIDE DERIVATIVE AND PREPARATION AND USE THEREOF | KCNB1, KCNB2, KCNA3 | KDM4E 247/4885HPGD 3002/4885TSHR 2382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.