Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 9/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 10/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2227597 | 0.92 | HDAC4 (0.48) | HDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2227491 | 0.84 | HDAC4 (0.46) | HDAC4HDAC6HDAC8GRM5HDAC2 | |
| SCHEMBL2227092 | 0.81 | HDAC6 (0.47) | HDAC4HDAC6HDAC8GRM5HDAC2 | |
| SCHEMBL2227593 | 0.78 | HDAC4 (0.48) | HDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2224982 | 0.77 | HDAC4 (0.57) | HDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2226069 | 0.76 | KDM4E (0.55) | HDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2224359 | 0.75 | PDK1 (0.49) | HDAC4HDAC6HDAC8GRM5HDAC2 | |
| SCHEMBL2227516 | 0.75 | FASN (0.49) | HDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2227381 | 0.74 | HDAC4 (0.67) | HDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2225388 | 0.74 | HDAC4 (0.63) | HDAC4HDAC6HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523664-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088192-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |