Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15283881 | 0.83 | L3MBTL1 (0.38) | L3MBTL1LMNAPOLBRAB9AATM | |
| SCHEMBL25269614 | 0.83 | LOXL2 (0.40) | L3MBTL1LMNAPOLBRAB9AATM | |
| SCHEMBL15284143 | 0.83 | POLB (0.38) | L3MBTL1LMNAPOLBRAB9AATM | |
| SCHEMBL861151 | 0.83 | L3MBTL1 (0.40) | L3MBTL1LMNAPOLBRAB9AATM | |
| SCHEMBL18667064 | 0.79 | L3MBTL1 (0.43) | L3MBTL1LMNAPOLBRAB9AATM | |
| SCHEMBL2060454 | 0.78 | POLB (0.44) | L3MBTL1LMNAPOLBRAB9AATM | |
| SCHEMBL21250399 | 0.78 | L3MBTL1 (0.36) | L3MBTL1LMNAPOLBRAB9AATM | |
| SCHEMBL861090 | 0.78 | L3MBTL1 (0.38) | L3MBTL1LMNAPOLBRAB9AATM | |
| SCHEMBL25184349 | 0.77 | L3MBTL1 (0.34) | L3MBTL1LMNAPOLBRAB9AATM | |
| Bromide SCHEMBL15009498 | 0.77 | L3MBTL1 (0.38) | L3MBTL1LMNAPOLBRAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112204036-B | Macrocyclic fused pyrazoles as MCL-1 inhibitors | 苏州亚盛药业有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-112204036-A | Macrocyclic fused pyrazoles as MCL-1 inhibitors | 苏州亚盛药业有限公司 | 2021-01-08 | — | — | CN | disclosed |
| WO-2020151738-A1 | MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2020-07-30 | — | — | WO | disclosed |