Sugi Predict

Sugi Predict / Compounds / SCHEMBL2227644

SCHEMBL2227644

SCHEMBL2227644

CCCOc1nc(NC2CCOCC2)nc2oc(-c3cccc(C)c3)nc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.39
▸ NPC1 O15118 2/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ LMNA P02545 2/20 0.39
▸ HPGD P15428 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ MAPK1 P28482 4/20 0.38
▸ CCNA2 P20248 2/20 0.38
▸ CDK2 P24941 2/20 0.38
▸ MAPK3 P27361 1/20 0.38
▸ PDE5A O76074 1/20 0.38
▸ GAA P10253 1/20 0.35
▸ MKNK1 Q9BUB5 1/20 0.35
▸ ADORA3 P0DMS8 3/20 0.34
▸ ADORA2A P29274 3/20 0.34
▸ ADORA2B P29275 3/20 0.34
▸ ADORA1 P30542 3/20 0.34
▸ MAPT P10636 2/20 0.34
▸ GABRA5 P31644 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1828263 0.77 RAB9A (0.39) KDM4ENPC1RAB9AALDH1A1LMNA
SCHEMBL1828532 0.76 MAPT (0.38) KDM4ENPC1RAB9AALDH1A1HPGD
SCHEMBL2225576 0.76 RAB9A (0.39) KDM4ENPC1RAB9AALDH1A1LMNA
SCHEMBL14974284 0.75 MAPT (0.42) KDM4ENPC1RAB9AALDH1A1HPGD
SCHEMBL1828489 0.74 SDHB (0.39) KDM4ENPC1RAB9AALDH1A1HPGD
SCHEMBL2224679 0.72 RAB9A (0.36) KDM4ENPC1RAB9AALDH1A1HPGD
SCHEMBL1831253 0.72 MAPT (0.39) KDM4ENPC1RAB9AALDH1A1HPGD
SCHEMBL1830757 0.72 PBRM1 (0.36) KDM4ENPC1RAB9AALDH1A1LMNA
SCHEMBL1829407 0.71 MAPT (0.38) KDM4ENPC1RAB9AALDH1A1LMNA
SCHEMBL2316875 0.70 RXFP1 (0.35) KDM4ENPC1RAB9AALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8785439-B2 2,5,7-substituted oxazolopyrimidine derivatives SANOFI (FR) 2014-07-22 — — US disclosed
US-8785439-B2 2,5,7-substituted oxazolopyrimidine derivatives SANOFI (FR) 2014-07-22 — — US disclosed
US-8785439-B2 2,5,7-substituted oxazolopyrimidine derivatives SANOFI (FR) 2014-07-22 — — US disclosed
EP-2523961-B1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI SA (FR) 2013-12-18 — — EP disclosed
US-20130137685-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI (FR) 2013-05-30 — — US disclosed
US-20130137685-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI (FR) 2013-05-30 — — US disclosed
US-20130137685-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI (FR) 2013-05-30 — — US disclosed
EP-2523961-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI (FR) 2012-11-21 — — EP disclosed
WO-2011086075-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI-AVENTIS (FR) 2011-07-21 — — WO disclosed
WO-2011086075-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES SANOFI-AVENTIS (FR) 2011-07-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130137685-A1 2,5,7-SUBSTITUTED OXAZOLOPYRIMIDINE DERIVATIVES DPYD, UNG, CDK2 KDM4E 1444/4885NPC1 4691/4885RAB9A 3663/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.