Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.98 |
| ▸ | NPC1 | O15118 | 12/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.98 |
| ▸ | MAPT | P10636 | 10/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.98 |
| ▸ | HPGD | P15428 | 8/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.98 |
| ▸ | HTT | P42858 | 5/20 | 0.98 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.76 |
| ▸ | LMNA | P02545 | 4/20 | 0.76 |
| ▸ | TP53 | P04637 | 3/20 | 0.76 |
| ▸ | CASP1 | P29466 | 2/20 | 0.76 |
| ▸ | CASP7 | P55210 | 2/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.76 |
| ▸ | CASP3 | P42574 | 1/20 | 0.76 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.76 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.76 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11962837 | 0.78 | HSD17B10 (0.64) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL22276733 | 0.78 | HSD17B10 (0.62) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL7061181 | 0.74 | NPC1 (0.64) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL7066787 | 0.73 | NPC1 (0.63) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL11951619 | 0.72 | HSD17B10 (0.57) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL11895019 | 0.71 | KDM4E (0.62) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL16934910 | 0.68 | KMT2A (0.85) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL11931415 | 0.68 | RAB9A (0.76) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL3706419 | 0.68 | MAPT (0.71) | RAB9ANPC1KDM4EMAPTALDH1A1 | |
| SCHEMBL903271 | 0.67 | PIM1 (0.56) | RAB9ANPC1KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200239479-A1 | Pyrazolopyrimidine Modulators of RAS GTPase | TOSK, INC. | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200239479-A1 | Pyrazolopyrimidine Modulators of RAS GTPase | KRAS, NRAS, HRAS | RAB9A 66/4885NPC1 3490/4885KDM4E 3433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.