Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.58 |
| ▸ | HPGD | P15428 | 8/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL940827 | 0.83 | KDM4E (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL463061 | 0.78 | KDM4E (0.74) | KDM4EALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL22276915 | 0.78 | SMN1; SMN2 (0.57) | KDM4EALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL29720155 | 0.76 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL9834241 | 0.74 | CKS1B (0.64) | KDM4EALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL21306288 | 0.72 | ADORA3 (0.49) | KDM4EALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL20511355 | 0.70 | TDP1 (0.49) | SMN1; SMN2LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20511415 | 0.70 | PDE10A (0.42) | SMN1; SMN2MEN1KMT2APDE10ATP53 | |
| SCHEMBL18000480 | 0.70 | MAPT (0.69) | KDM4EALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL17966388 | 0.69 | MAPT (0.77) | KDM4EALDH1A1HPGDSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200239479-A1 | Pyrazolopyrimidine Modulators of RAS GTPase | TOSK, INC. | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200239479-A1 | Pyrazolopyrimidine Modulators of RAS GTPase | KRAS, NRAS, HRAS | KDM4E 3433/4885ALDH1A1 3923/4885HPGD 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.