Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.36 |
| ▸ | RELA | Q04206 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21937449 | 0.81 | MCHR1 (0.60) | MCHR1SMN1; SMN2ALDH1A1NPC1KDM4E | |
| SCHEMBL22277247 | 0.74 | MCHR1 (0.45) | MCHR1SMN1; SMN2ALDH1A1NPC1KDM4E | |
| SCHEMBL720360 | 0.70 | SMN1; SMN2 (0.50) | MCHR1SMN1; SMN2ALDH1A1NPC1KDM4E | |
| SCHEMBL23502136 | 0.68 | SCN10A (0.62) | MCHR1SMN1; SMN2ALDH1A1NPC1KDM4E | |
| SCHEMBL23571404 | 0.67 | SMN1; SMN2 (0.55) | MCHR1SMN1; SMN2ALDH1A1NPC1KDM4E | |
| SCHEMBL16386820 | 0.65 | RAB9A (0.51) | MCHR1SMN1; SMN2ALDH1A1NPC1KDM4E | |
| SCHEMBL3340576 | 0.65 | SMN1; SMN2 (0.54) | MCHR1SMN1; SMN2ALDH1A1NPC1KDM4E | |
| SCHEMBL798511 | 0.64 | MCHR1 (0.45) | MCHR1SMN1; SMN2ALDH1A1NPC1KDM4E | |
| SCHEMBL12197120 | 0.62 | APP (0.46) | MCHR1SMN1; SMN2ALDH1A1NPC1KDM4E | |
| SCHEMBL8814197 | 0.62 | MCHR1 (0.57) | MCHR1SMN1; SMN2ALDH1A1NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11168083-B2 | Inhibitors of Plasma Kallikrein and uses thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-11-09 | — | — | US | disclosed |
| US-20200239463-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11168083-B2 | Inhibitors of Plasma Kallikrein and uses thereof | KLKB1, KLK1, KLK5 | MCHR1 2156/4885SMN1; SMN2 4555/4885ALDH1A1 3858/4885 |
| US-20200239463-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | KLKB1, KLK1, KLK5 | MCHR1 2156/4885SMN1; SMN2 4555/4885ALDH1A1 3858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.