Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Benzil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 12/20 | 0.93 |
| ▸ | CES1 | P23141 | 12/20 | 0.93 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | DAO | P14920 | 1/20 | 0.61 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA4 | P22748 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzil SCHEMBL28859327 | 1.00 | CES2 (0.93) | CES2CES1TSHRDAONAPRT | |
| Benzil SCHEMBL2156589 | 0.97 | CES2 (1.00) | CES2CES1TSHRDAONAPRT | |
| Benzil SCHEMBL66 | 0.97 | CES2 (1.00) | CES2CES1TSHRDAONAPRT | |
| Benzil SCHEMBL28475956 | 0.97 | CES2 (1.00) | CES2CES1TSHRDAONAPRT | |
| Benzil SCHEMBL9517636 | 0.97 | CES2 (1.00) | CES2CES1TSHRDAONAPRT | |
| Benzil SCHEMBL7142843 | 0.97 | CES2 (1.00) | CES2CES1TSHRDAONAPRT | |
| Benzil SCHEMBL1002038 | 0.93 | CES2 (0.93) | CES2CES1TSHRDAONAPRT | |
| Benzil SCHEMBL9799726 | 0.93 | CES2 (0.93) | CES2CES1TSHRDAONAPRT | |
| Benzil SCHEMBL10996187 | 0.93 | CES2 (0.93) | CES2CES1TSHRDAONAPRT | |
| Benzil SCHEMBL4957522 | 0.93 | CES2 (1.00) | CES2CES1TSHRDAONAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8465553-B2 | Pigment dispersion composition, colored curable composition, color filter for solid-state image sensor and method of producing the same, and solid-state image sensor | FUJIFILM CORPORATION (JP) | 2013-06-18 | — | — | US | disclosed |
| EP-2524007-A1 | PIGMENT DISPERSION COMPOSITION, COLORED CURABLE COMPOSITION, COLOR FILTER FOR SOLID-STATE IMAGE SENSOR AND METHOD OF PRODUCING THE SAME, AND SOLID-STATE IMAGE SENSOR | FUJIFILM Corporation (JP) | 2012-11-21 | — | — | EP | disclosed |
| US-20120286145-A1 | PIGMENT DISPERSION COMPOSITION, COLORED CURABLE COMPOSITION, COLOR FILTER FOR SOLID-STATE IMAGE SENSOR AND METHOD OF PRODUCING THE SAME, AND SOLID-STATE IMAGE SENSOR | FUJIFILM CORPORATION (JP) | 2012-11-15 | — | — | US | disclosed |
| WO-2011087114-A1 | PIGMENT DISPERSION COMPOSITION, COLORED CURABLE COMPOSITION, COLOR FILTER FOR SOLID-STATE IMAGE SENSOR AND METHOD OF PRODUCING THE SAME, AND SOLID-STATE IMAGE SENSOR | FUJIFILM CORPORATION (JP) | 2011-07-21 | — | — | WO | disclosed |
| US-20040059096-A1 | Anti-ciguatoxin monoclonal antibody | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2004-03-25 | — | — | US | disclosed |
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| EP-1337333-A1 | CATALYST SYSTEM FOR THE POLYMERIZATION OF OLEFINS | Basell Polyolefine GmbH (DE) | 2003-08-27 | — | — | EP | disclosed |
| US-20030017939-A1 | Catalyst system for the polymerization of olefins | OKUMURA YOSHIKUNI (DE) | 2003-01-23 | — | — | US | disclosed |
| WO-2002038270-A1 | CATALYST SYSTEM FOR THE POLYMERIZATION OF OLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2002-05-16 | — | — | WO | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |
| US-5468897-A | Bi-aromatic esters, a process for their preparation and their use in human or veterinary medicine and in cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1995-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040059096-A1 | Anti-ciguatoxin monoclonal antibody | PBK, IK, KLRK1 | CES2 4412/4885CES1 3747/4885TSHR 1890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.