Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22278511 | 0.90 | HPGD (0.49) | RORCHPGDGAACYP11B1CYP11B2 | |
| SCHEMBL22278490 | 0.89 | RORC (0.47) | RORCHPGDGAACYP11B1CYP11B2 | |
| SCHEMBL22278716 | 0.89 | RORC (0.46) | RORCHPGDGAACYP11B1CYP11B2 | |
| SCHEMBL22278690 | 0.86 | RORC (0.47) | RORCHPGDGAAKDM2BL3MBTL1 | |
| SCHEMBL22278745 | 0.85 | RORC (0.43) | RORCHPGDGAACYP11B1CYP11B2 | |
| SCHEMBL22278556 | 0.85 | RORC (0.46) | RORCHPGDGAACYP11B1CYP11B2 | |
| SCHEMBL22278483 | 0.83 | RORC (0.43) | RORCHPGDGAAHTR6SMN1; SMN2 | |
| SCHEMBL22278560 | 0.83 | RORC (0.44) | RORCCYP11B1CYP11B2KDM2BL3MBTL1 | |
| SCHEMBL22278612 | 0.83 | RORC (0.44) | RORCCYP11B1CYP11B2KDM2BL3MBTL1 | |
| SCHEMBL24061139 | 0.82 | RORC (0.44) | RORCHPGDHTR6POLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3915977-A1 | 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2021-12-01 | — | — | EP | disclosed |
| WO-2020151232-A1 | 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海和誉生物医药科技有限公司 | 2020-07-30 | — | — | WO | disclosed |