Clofibric Acid

Clofibric Acid

SCHEMBL2227936

CC(C)(Oc1ccc(Cl)cc1)C(=O)O.CC(C)(Oc1ccc(Cl)cc1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 15/20 1.00
CYP1A2 P05177 2/20 1.00
CYP3A4 P08684 2/20 1.00
MEN1 O00255 1/20 1.00
CYP2D6 P10635 1/20 1.00
MAPT P10636 1/20 1.00
CYP2C19 P33261 1/20 1.00
KMT2A Q03164 1/20 1.00
PPARG P37231 5/20 0.83
FABP2 P12104 2/20 0.83
SLC22A12 Q96S37 1/20 0.83
TSHR P16473 2/20 0.62
ABCB11 O95342 1/20 0.62
HTR2A P28223 1/20 0.62
PMP22 Q01453 1/20 0.62
PPARD Q03181 3/20 0.61
PSEN1 P49768 3/20 0.61
PSEN2 P49810 3/20 0.61
APH1B Q8WW43 3/20 0.61
NCSTN Q92542 3/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Clofibric Acid SCHEMBL102826 1.00 PPARA (1.00) PPARACYP1A2CYP3A4MEN1CYP2D6
Clofibric Acid SCHEMBL10634899 0.98 PPARA (0.96) PPARACYP1A2CYP3A4MEN1CYP2D6
Clofibric Acid SCHEMBL28722594 0.98 PPARA (0.96) PPARACYP1A2CYP3A4MEN1CYP2D6
Clofibric Acid SCHEMBL317991 0.98 PPARA (0.96) PPARACYP1A2CYP3A4MEN1CYP2D6
Clofibric Acid SCHEMBL11798397 0.98 PPARA (0.96) PPARACYP1A2CYP3A4MEN1CYP2D6
Clofibric Acid SCHEMBL11798234 0.98 PPARA (0.96) PPARACYP1A2CYP3A4MEN1CYP2D6
Clofibric Acid SCHEMBL28571877 0.98 PPARA (0.96) PPARACYP1A2CYP3A4MEN1CYP2D6
Clofibric Acid SCHEMBL11798560 0.96 PPARA (0.93) PPARACYP1A2CYP3A4MEN1CYP2D6
SCHEMBL6350219 0.94 PPARA (0.89) PPARACYP1A2CYP3A4MEN1CYP2D6
SCHEMBL9320807 0.94 PPARA (0.89) PPARACYP1A2CYP3A4MEN1CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011090726-A2 USE OF A NATURAL METABOLITE TO INCREASE CROP PRODUCTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-07-28 WO disclosed
WO-2011090727-A2 MITIGATION OF ALTERNATE BEARING THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-07-28 WO disclosed