Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Clofibric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 5/20 | 0.81 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.60 |
| ▸ | PDE5A known ✓ | O76074 | 1/20 | 0.57 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.57 |
| ▸ | PPARA | Q07869 | 15/20 | 0.96 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.96 |
| ▸ | MEN1 | O00255 | 1/20 | 0.96 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.96 |
| ▸ | MAPT | P10636 | 1/20 | 0.96 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.96 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.96 |
| ▸ | FABP2 | P12104 | 2/20 | 0.81 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.81 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | PPARD | Q03181 | 3/20 | 0.59 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.59 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clofibric Acid SCHEMBL2227936 | 0.98 | PPARA (1.00) | PPARACYP1A2CYP3A4MEN1CYP2D6 | |
| Clofibric Acid SCHEMBL102826 | 0.98 | PPARA (1.00) | PPARACYP1A2CYP3A4MEN1CYP2D6 | |
| Clofibric Acid SCHEMBL28722594 | 0.96 | PPARA (0.96) | PPARACYP1A2CYP3A4MEN1CYP2D6 | |
| Clofibric Acid SCHEMBL28571877 | 0.96 | PPARA (0.96) | PPARACYP1A2CYP3A4MEN1CYP2D6 | |
| Clofibric Acid SCHEMBL11798397 | 0.96 | PPARA (0.96) | PPARACYP1A2CYP3A4MEN1CYP2D6 | |
| Clofibric Acid SCHEMBL317991 | 0.96 | PPARA (0.96) | PPARACYP1A2CYP3A4MEN1CYP2D6 | |
| Clofibric Acid SCHEMBL11798234 | 0.96 | PPARA (0.96) | PPARACYP1A2CYP3A4MEN1CYP2D6 | |
| Clofibric Acid SCHEMBL11798560 | 0.94 | PPARA (0.93) | PPARACYP1A2CYP3A4MEN1CYP2D6 | |
| SCHEMBL6350219 | 0.93 | PPARA (0.89) | PPARACYP1A2CYP3A4MEN1CYP2D6 | |
| SCHEMBL9320807 | 0.93 | PPARA (0.89) | PPARACYP1A2CYP3A4MEN1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE32581-E | Certain substituted phenyl esters of nicotinic acid, compositions and methods of using same for treatment of hyperlipidemia | MERZ + CO. GMBH & CO. (DE) | 1988-01-19 | — | — | US | disclosed |
| US-4412998-A | ANTILIPEMIC | MERZ & COMPANY (DE) | 1983-11-01 | — | — | US | disclosed |
| US-4321268-A | Certain substituted phenyl esters of nicotinic acid, compositions and methods of using same | MERZ & CO. (DE) | 1982-03-23 | — | — | US | disclosed |
| US-4176193-A | ANTILIPEMIC, ANTICHLOESTEROL AGENTS | SOCIETE D'ETUDES DE PRODUITS CHIMIQUES (FR) | 1979-11-27 | — | — | US | disclosed |
| US-4166861-A | ESTERS OF CATECHIN AND EPICATECHIN; ANTILIPEMIC, ANTICHOLESTEROL, HEPATOPROTECTIVE | INVERNI DELLA BEFFA S.P.A. (IT) | 1979-09-04 | — | — | US | disclosed |
| US-4140770-A | Benzoylethers and processes for their production | A. NATTERMANN & CIE. GMBH (DE) | 1979-02-20 | — | — | US | disclosed |
| US-4118583-A | ANTICOAGULANT, ANTICHOLINERGIC AGENTS | LABORATORIES OM SOCIETE ANONYME (CH) | 1978-10-03 | — | — | US | disclosed |
| US-4067726-A | 3-Ureido phenylacetamide herbicides | BAYER AKTIENGESELLSCHAFT (DT) | 1978-01-10 | — | — | US | disclosed |
| US-4001447-A | HAVING HYPOLIPEMIANT, VASODILATATORY AND HYPOCHOLESTEROLEMIANT ACTIVITIES | ROUSSEL-UCLAF (FR) | 1977-01-04 | — | — | US | disclosed |