Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 8/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18383137 | 0.81 | MAP3K7 (0.47) | MAP3K7TAB1CHUKLRRK2HSP90AB1 | |
| SCHEMBL22280088 | 0.81 | CHUK (0.47) | MAP3K7TAB1CHUKLRRK2HSP90AB1 | |
| SCHEMBL31095312 | 0.76 | CHUK (0.71) | CHUKLRRK2HSP90AB1HSP90AA1ROCK2 | |
| SCHEMBL19010829 | 0.76 | CHUK (0.71) | CHUKLRRK2HSP90AB1HSP90AA1ROCK2 | |
| SCHEMBL24136246 | 0.74 | CHUK (0.68) | CHUKLRRK2HSP90AB1HSP90AA1ROCK2 | |
| SCHEMBL19010828 | 0.73 | CHUK (0.43) | MAP3K7TAB1CHUKLRRK2HSP90AB1 | |
| SCHEMBL22280368 | 0.71 | CHUK (0.51) | CHUKLRRK2HSP90AB1HSP90AA1ROCK2 | |
| SCHEMBL22280371 | 0.70 | CNR1 (0.44) | CHUKLRRK2ROCK2ROCK1CDC42BPB | |
| SCHEMBL5723781 | 0.70 | PIN1 (0.55) | LMNACNR1CNR2 | |
| SCHEMBL22280369 | 0.69 | CHUK (0.54) | CHUKLRRK2HSP90AB1HSP90AA1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11208412-B2 | Pyrrolo-pyrimidine derivative compound, preparation method therefor, and pharmaceutical composition comprising same compound as effective ingredient for preventing or treating protein kinase-related disease | DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION (KR) | 2021-12-28 | — | — | US | disclosed |
| US-20200239474-A1 | PYRROLO-PYRIMIDINE DERIVATIVE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME COMPOUND AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE | DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION (KR) | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11208412-B2 | Pyrrolo-pyrimidine derivative compound, preparation method therefor, and pharmaceutical composition comprising same compound as effective ingredient for preventing or treating protein kinase-related disease | LRRK2, WEE1, WEE2 | MAP3K7 153/4885TAB1 527/4885CHUK 653/4885 |
| US-20200239474-A1 | PYRROLO-PYRIMIDINE DERIVATIVE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME COMPOUND AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASE | LRRK2, WEE1, WEE2 | MAP3K7 153/4885TAB1 527/4885CHUK 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.