Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.57 |
| ▸ | CDK4 | P11802 | 4/20 | 0.57 |
| ▸ | CDK2 | P24941 | 4/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229802 | 0.92 | MKNK1 (0.47) | GSK3BDYRK1ACDK4CDK2MKNK1 | |
| SCHEMBL2229402 | 0.90 | ADORA2B (0.45) | GSK3BDYRK1ACDK4CDK2MKNK1 | |
| SCHEMBL2228389 | 0.89 | MKNK1 (0.46) | GSK3BDYRK1ACDK4CDK2MKNK1 | |
| SCHEMBL2228210 | 0.89 | GSK3B (0.53) | GSK3BDYRK1ACDK4CDK2MKNK1 | |
| SCHEMBL2228014 | 0.88 | CDK2 (0.45) | GSK3BDYRK1ACDK4CDK2MKNK1 | |
| SCHEMBL2226944 | 0.87 | CDK2 (0.43) | GSK3BDYRK1ACDK4CDK2MKNK1 | |
| SCHEMBL2229329 | 0.87 | MKNK1 (0.43) | GSK3BDYRK1ACDK4CDK2MKNK1 | |
| SCHEMBL2230002 | 0.87 | CDK2 (0.43) | GSK3BDYRK1ACDK4CDK2MKNK1 | |
| SCHEMBL2227344 | 0.87 | DYRK1A (0.57) | GSK3BDYRK1ACDK4CDK2MKNK1 | |
| SCHEMBL2228358 | 0.86 | MKNK1 (0.52) | GSK3BDYRK1ACDK4CDK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | GOTO YASUHIRO | 2011-07-28 | — | — | US | disclosed |
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | GOTO YASUHIRO | 2011-07-28 | — | — | US | disclosed |
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | GOTO YASUHIRO | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | BRIX1, REL, CNKSR1 | GSK3B 2618/4885DYRK1A 1517/4885CDK4 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.