Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.67 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | GRM5 | P41594 | 9/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280465 | 0.90 | RAB9A (0.60) | SPHK2SPHK1RAB9ANPC1GRM5 | |
| SCHEMBL22280439 | 0.90 | RAB9A (0.60) | SPHK2SPHK1RAB9ANPC1GRM5 | |
| SCHEMBL22280297 | 0.89 | MAPK1 (0.64) | SPHK2SPHK1RAB9ANPC1GRM5 | |
| SCHEMBL22280266 | 0.89 | MAPK1 (0.64) | SPHK2SPHK1RAB9ANPC1GRM5 | |
| SCHEMBL22280441 | 0.88 | RAB9A (0.64) | SPHK2SPHK1RAB9ANPC1GRM5 | |
| SCHEMBL16934245 | 0.81 | SPHK2 (1.00) | SPHK2SPHK1 | |
| SCHEMBL16934032 | 0.81 | SPHK2 (1.00) | SPHK2SPHK1 | |
| Hydrochloric Acid SCHEMBL22265475 | 0.80 | SPHK2 (0.98) | SPHK2SPHK1 | |
| Hydrochloric Acid SCHEMBL22265520 | 0.80 | SPHK2 (0.98) | SPHK2SPHK1 | |
| Hydrochloric Acid SCHEMBL15175635 | 0.80 | SPHK2 (0.98) | SPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |