Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.57 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.54 |
| ▸ | TUBB | P07437 | 3/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280465 | 1.00 | RAB9A (0.60) | RAB9ANPC1SPHK2SPHK1LMNA | |
| SCHEMBL22280266 | 0.94 | MAPK1 (0.64) | RAB9ANPC1SPHK2SPHK1LMNA | |
| SCHEMBL22280297 | 0.94 | MAPK1 (0.64) | RAB9ANPC1SPHK2SPHK1LMNA | |
| SCHEMBL22280441 | 0.93 | RAB9A (0.64) | RAB9ANPC1SPHK2SPHK1LMNA | |
| SCHEMBL22280462 | 0.90 | SPHK2 (0.67) | RAB9ANPC1SPHK2SPHK1LMNA | |
| SCHEMBL22280622 | 0.88 | HSD11B1 (0.63) | SPHK2SPHK1TUBB4ATUBBTUBA3C | |
| SCHEMBL22280479 | 0.86 | MAPK1 (0.49) | RAB9ANPC1SPHK2SPHK1LMNA | |
| SCHEMBL16934051 | 0.82 | SPHK2 (0.85) | SPHK2SPHK1 | |
| SCHEMBL22266151 | 0.82 | SPHK2 (0.85) | SPHK2SPHK1 | |
| SCHEMBL22280489 | 0.82 | SPHK2 (0.48) | RAB9ASPHK2SPHK1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |