Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280469 | 0.72 | CDK4 (0.33) | KDM4EPOLBALOX15KMT2AMEN1 | |
| SCHEMBL4491812 | 0.69 | HDAC1 (0.47) | HDAC1HDAC6KDM4EPOLBADRA2A | |
| SCHEMBL4491815 | 0.69 | HDAC1 (0.47) | HDAC1HDAC6KDM4EPOLBADRA2A | |
| SCHEMBL5431595 | 0.67 | HDAC1 (0.46) | HDAC1HDAC6KDM4EPOLBALOX15 | |
| SCHEMBL19779264 | 0.67 | HDAC1 (0.48) | HDAC1HDAC6KDM4EPOLBADRA2A | |
| SCHEMBL24233739 | 0.66 | PADI4 (0.33) | POLBALOX15MAPTHRH1 | |
| SCHEMBL31145160 | 0.66 | PADI4 (0.38) | HDAC1HDAC6KDM4EPOLBALOX15 | |
| SCHEMBL24365575 | 0.66 | PADI4 (0.38) | HDAC1HDAC6KDM4EPOLBALOX15 | |
| SCHEMBL29362978 | 0.65 | ADRA2A (0.48) | HDAC1HDAC6KDM4EPOLBALOX15 | |
| SCHEMBL641281 | 0.65 | ADRA2A (0.48) | HDAC1HDAC6KDM4EPOLBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |