Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22265485 | 0.75 | F10 (0.35) | MEN1MAPTHPGDKMT2AKDM4E | |
| SCHEMBL22265486 | 0.75 | F10 (0.35) | MEN1MAPTHPGDKMT2AKDM4E | |
| SCHEMBL22280472 | 0.72 | HDAC1 (0.37) | MEN1MAPTALOX15KMT2AKDM4E | |
| SCHEMBL22280456 | 0.63 | IGF1R (0.33) | — | |
| SCHEMBL22265325 | 0.62 | HTT (0.38) | MEN1ALOX15KMT2ALMNA | |
| SCHEMBL14696572 | 0.57 | TYK2 (0.43) | CDK2HPGDKMT2A | |
| SCHEMBL3849741 | 0.55 | SORT1 (0.45) | MEN1TP53MAPTHPGDALOX15 | |
| SCHEMBL11322821 | 0.54 | HTT (0.43) | MEN1MAPTKMT2ALMNA | |
| SCHEMBL11322817 | 0.54 | HTT (0.43) | MEN1MAPTKMT2ALMNA | |
| SCHEMBL14696131 | 0.54 | HCAR3 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |