Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | GRM5 | P41594 | 4/20 | 0.51 |
| ▸ | CLPP | Q16740 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280317 | 0.92 | FAAH (0.51) | HDAC4HDAC6GRM5 | |
| SCHEMBL29523313 | 0.91 | HDAC4 (0.54) | HDAC4HDAC6GRM5CLPPRAB9A | |
| SCHEMBL29523752 | 0.90 | HDAC4 (0.53) | HDAC4HDAC6GRM5CLPPRAB9A | |
| SCHEMBL19472882 | 0.86 | SPHK2 (0.53) | GRM5 | |
| SCHEMBL192613 | 0.85 | ALDH1A1 (0.64) | HDAC4HDAC6GRM5CLPPRAB9A | |
| SCHEMBL22280436 | 0.85 | ALDH1A1 (0.64) | HDAC4HDAC6GRM5CLPPRAB9A | |
| SCHEMBL5769537 | 0.85 | ALDH1A1 (0.64) | HDAC4HDAC6GRM5CLPPRAB9A | |
| SCHEMBL29523421 | 0.85 | HTT (0.52) | HDAC4HDAC6GRM5CLPPRAB9A | |
| SCHEMBL29523364 | 0.85 | HTT (0.52) | HDAC4HDAC6GRM5CLPPRAB9A | |
| SCHEMBL193106 | 0.84 | GRM5 (0.71) | HDAC4HDAC6GRM5CLPPRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |