Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | ACACA | Q13085 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19287107 | 0.89 | S1PR2 (0.56) | SMN1; SMN2RAB9ANPC1HTTATM | |
| SCHEMBL24386291 | 0.85 | SIRT2 (0.55) | SMN1; SMN2RAB9ANPC1HTTTP53 | |
| SCHEMBL5378065 | 0.81 | S1PR1 (0.58) | SMN1; SMN2RAB9ANPC1HTTMAPT | |
| SCHEMBL16975850 | 0.81 | SMN1; SMN2 (0.71) | SMN1; SMN2RAB9ANPC1HTTMAPT | |
| SCHEMBL28930115 | 0.81 | TSHR (0.49) | SMN1; SMN2RAB9ANPC1HTTHTR1A | |
| SCHEMBL10914161 | 0.80 | RAB9A (0.69) | SMN1; SMN2RAB9ANPC1HTTHTR1A | |
| SCHEMBL15632850 | 0.79 | L3MBTL1 (0.66) | SMN1; SMN2RAB9ANPC1HTTMAPT | |
| SCHEMBL15633723 | 0.79 | L3MBTL1 (0.70) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL14288613 | 0.79 | RAB9A (0.70) | SMN1; SMN2RAB9ANPC1HTTHTR1A | |
| SCHEMBL19131259 | 0.79 | SMN1; SMN2 (0.64) | SMN1; SMN2RAB9ANPC1HTTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |