Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280449 | 1.00 | NR1H4 (0.44) | NR1H4TLR9TLR8TLR7SYK | |
| Hydrochloric Acid SCHEMBL22265521 | 0.99 | NR1H4 (0.43) | NR1H4TLR9TLR8TLR7SYK | |
| Hydrochloric Acid SCHEMBL22265524 | 0.99 | NR1H4 (0.43) | NR1H4TLR9TLR8TLR7SYK | |
| SCHEMBL22280442 | 0.82 | NPC1 (0.48) | NR1H4TLR9TLR8TLR7LMNA | |
| SCHEMBL22265627 | 0.81 | LMNA (0.49) | MEN1LMNAMAPTHTTRECQL | |
| SCHEMBL22265631 | 0.81 | LMNA (0.49) | MEN1LMNAMAPTHTTRECQL | |
| SCHEMBL22280535 | 0.80 | LMNA (0.45) | MEN1LMNAMAPTHTTRECQL | |
| Hydrochloric Acid SCHEMBL22266011 | 0.79 | LMNA (0.45) | MEN1LMNAMAPTHTTRECQL | |
| SCHEMBL22280267 | 0.79 | NR1H4 (0.49) | NR1H4TLR9TLR8TLR7GRM5 | |
| SCHEMBL29523141 | 0.78 | LMNA (0.47) | MEN1LMNAMAPTHTTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |