Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14679172 | 0.86 | LMNA (0.57) | MAPTLMNAHTTTSHRHPGD | |
| SCHEMBL29496372 | 0.86 | SPHK1 (0.53) | HDAC2HDAC8HDAC1LMNATSHR | |
| SCHEMBL22280639 | 0.78 | TP53 (0.49) | HDAC2HDAC8HDAC1MAPTLMNA | |
| SCHEMBL14679175 | 0.76 | MAPT (0.58) | HDAC2HDAC8HDAC1MAPTLMNA | |
| SCHEMBL25802137 | 0.75 | MAPT (0.50) | HDAC2HDAC8HDAC1MAPTLMNA | |
| SCHEMBL3107401 | 0.74 | LMNA (0.45) | MAPTLMNAHTTTSHRMAPK1 | |
| SCHEMBL24326607 | 0.74 | ALDH1A1 (0.77) | HDAC2HDAC8HDAC1MAPTLMNA | |
| SCHEMBL14679174 | 0.74 | MAPT (0.66) | HDAC2HDAC8HDAC1MAPTTSHR | |
| SCHEMBL15264021 | 0.72 | KCNH2 (0.42) | HDAC2HDAC1LMNAL3MBTL1NPC1 | |
| SCHEMBL24326634 | 0.71 | TDP1 (0.69) | HDAC2HDAC8HDAC1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |