Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280630 | 0.77 | GRM5 (0.41) | KDM4EMAPTMEN1KMT2AHDAC3 | |
| SCHEMBL12590937 | 0.72 | KDM4E (0.59) | KDM4EGAAMAPTEGFRMEN1 | |
| SCHEMBL12590929 | 0.72 | CCNK (0.36) | GAAMAPTMEN1KMT2A | |
| SCHEMBL22265526 | 0.71 | KDM4E (0.46) | KDM4EGAATYK2PDE4DMAPT | |
| SCHEMBL22265527 | 0.71 | KDM4E (0.46) | KDM4EGAATYK2PDE4DMAPT | |
| SCHEMBL22280476 | 0.70 | AURKA (0.45) | KDM4ETYK2MAPTMEN1KMT2A | |
| SCHEMBL22265306 | 0.69 | EGFR (0.47) | KDM4EGAATYK2PDE4DMAPT | |
| SCHEMBL22280456 | 0.68 | IGF1R (0.33) | — | |
| SCHEMBL28416838 | 0.68 | GRM4 (0.52) | KDM4ETYK2PDE4DMAPTEGFR | |
| SCHEMBL29408383 | 0.68 | GRM4 (0.52) | KDM4ETYK2PDE4DMAPTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |