Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 9/20 | 0.41 |
| ▸ | JAK1 | P23458 | 9/20 | 0.41 |
| ▸ | TYK2 | P29597 | 9/20 | 0.41 |
| ▸ | JAK3 | P52333 | 9/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280456 | 0.75 | IGF1R (0.33) | — | |
| SCHEMBL22280630 | 0.74 | GRM5 (0.41) | MAPTRAB9AHDAC3HDAC1HDAC2 | |
| SCHEMBL22280554 | 0.70 | KDM4E (0.41) | AURKATYK2MAPTHDAC3HDAC6 | |
| SCHEMBL22280477 | 0.68 | CNR2 (0.49) | AURKAJAK2JAK1TYK2JAK3 | |
| SCHEMBL11566527 | 0.67 | HCAR3 (0.65) | AURKAJAK2JAK1TYK2JAK3 | |
| SCHEMBL22265582 | 0.67 | F10 (0.49) | AURKAJAK2JAK1TYK2JAK3 | |
| SCHEMBL22265584 | 0.67 | F10 (0.49) | AURKAJAK2JAK1TYK2JAK3 | |
| SCHEMBL22266118 | 0.65 | FLT3 (0.54) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL7985717 | 0.64 | KMT2A (0.73) | AURKAJAK2JAK1TYK2JAK3 | |
| SCHEMBL4347258 | 0.64 | MEN1 (0.49) | AURKAJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |