Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.43 |
| ▸ | TUBB | P07437 | 2/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29523141 | 1.00 | LMNA (0.47) | LMNAHTTSMN1; SMN2MEN1MAPT | |
| SCHEMBL22265631 | 0.91 | LMNA (0.49) | LMNAHTTSMN1; SMN2MEN1MAPT | |
| SCHEMBL22265627 | 0.91 | LMNA (0.49) | LMNAHTTSMN1; SMN2MEN1MAPT | |
| SCHEMBL22280553 | 0.88 | SMN1; SMN2 (0.42) | LMNAHTTSMN1; SMN2MEN1MAPT | |
| SCHEMBL22265596 | 0.88 | SMN1; SMN2 (0.42) | LMNAHTTSMN1; SMN2MEN1MAPT | |
| SCHEMBL22265592 | 0.88 | SMN1; SMN2 (0.42) | LMNAHTTSMN1; SMN2MEN1MAPT | |
| SCHEMBL22265599 | 0.88 | SMN1; SMN2 (0.42) | LMNAHTTSMN1; SMN2MEN1MAPT | |
| SCHEMBL29523344 | 0.88 | SMN1; SMN2 (0.42) | LMNAHTTSMN1; SMN2MEN1MAPT | |
| SCHEMBL22280535 | 0.87 | LMNA (0.45) | LMNAHTTSMN1; SMN2MEN1MAPT | |
| SCHEMBL22280307 | 0.87 | MAPK1 (0.50) | LMNAHTTSMN1; SMN2MAPTTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |