Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.46 |
| ▸ | TUBB | P07437 | 3/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29523301 | 0.89 | SPHK2 (0.45) | MAPTALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL22280443 | 0.88 | HDAC6 (0.49) | MAPK1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL29523920 | 0.87 | SPHK2 (0.49) | MAPTALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL22280276 | 0.87 | LMNA (0.57) | MAPK1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL22280590 | 0.87 | LMNA (0.57) | MAPK1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL22280559 | 0.87 | LMNA (0.47) | MAPK1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL29523141 | 0.87 | LMNA (0.47) | MAPK1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL29523928 | 0.85 | SMO (0.47) | MAPTSMN1; SMN2LMNATSHRHTT | |
| SCHEMBL29522926 | 0.84 | HDAC6 (0.43) | MAPTALDH1A1SMN1; SMN2GPR119HDAC6 | |
| SCHEMBL22280479 | 0.84 | MAPK1 (0.49) | MAPK1MAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |